Everything about Endothelial Dysfunction totally explained
Endothelial dysfunction is a physiological
dysfunction of normal biochemical processes carried out by the
endothelium, the cells that line the inner surface of all blood vessels including arteries and veins (as well as the innermost lining of the heart and
lymphatics.) Compromise of normal function of endothelial cells is characteristic of endothelial dysfunction. Normal functions of endothelial cells include mediation of
coagulation, platelet adhesion, immune function, control of
volume and
electrolyte content of the intravascular and extravascular spaces. Endothelial dysfunction can result from disease processes, as occurs in
septic shock,
hypertension,
hypercholesterolaemia,
diabetes as well as from environmental factors, such as from smoking tobacco products.
Endothelial dysfunction is thought to be a key event in the development of
atherosclerosis and predates clinically obvious vascular pathology by many years. Endothelial dysfunction has also been shown to be of prognostic significance in predicting vascular events including stroke and heart attacks.
A key feature of endothelial dysfunction is the inability of
arteries and
arterioles to dilate fully in response to an appropriate stimulus. This can be tested by a variety of methods including
iontophoresis of
acetylcholine, intra-arterial administration of various vasoactive agents, localised heating of the skin and temporary arterial occlusion by inflating a
blood pressure cuff to high pressures. Testing can also take place in the coronary arteries themselves but this is invasive and not normally conducted unless there's a clinal reason for
intracoronary catheterisation. These techniques are thought to stimulate the endothelium to release
nitric oxide (NO) and possibly some other agents, which diffuse into the surrounding
vascular smooth muscle causing vasodilation.
Dysfunctional endothelial cells are unable to produce NO to the same extent (or there's increased and rapid destruction of NO) as healthy endothelial cells and therefore
vasodilatation is reduced. This creates a detectable difference in subjects with endothelial dysfunction verses a normal, healthy endothelium.
Unfortunately the variability in such tests means that no technique has yet been identified that would allow endothelial testing to attain routine clinical significance.
As more research is conducted to improve testing methodologies for endothelial dysfunction, however, several non-invasive tests have been created by various medical-research companies.
Endothelial function can be improved significantly by exercise and improved diet. A study published in
2005 has determined that a positive relationship exists between the consumption of
trans fat (commonly found in
hydrogenated products such as
margarine) and the development of endothelial dysfunction. Other factors have been identified as improving endothelial function and include cessation of smoking, loss of weight and treatment of
hypertension and
hypercholesterolemia amongst other things.
Endothelial dysfunction has been observed in a
2001 study of women where it was found that this disorder is present in approximately half of women with chest pain, in the absence of overt blockages in large coronary arteries. This endothelial dysfunction can't be predicted by typical risk factors for atherosclerosis (for example, obesity, cholesterol, smoking) and hormones.
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